PolyPhen-2 (Polymorphism Phenotyping v2) is a tool which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations. Please, use the form below to submit your query.
WHESS.db provides quick access to precomputed set of PolyPhen-2 predictions for whole human exome sequence space (WHESS). It contains annotations for all single-nucleotide non-synonymous (missense) codon changes enumerated at each CDS codon position in the exons of 43,043 UCSC knownGene transcripts (hg19/GRCh37) with maximum sequence overlap and identity to known UniProtKB proteins.