PolyPhen-2 prediction of functional effects of human nsSNPs

PolyPhen-2 (Polymorphism Phenotyping v2) is a tool which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations. Please, use the form below to submit your query.

15-Feb-2012:  PolyPhen-2 server has been updated to utilize version 2.2.2 of the software, protein sequences from UniProtKB/UniRef100 Release 2011_12 (14-Dec-2011), structures from PDB/DSSP Snapshot 03-Jan-2012 (78,304 entries) and UCSC MultiZ multiple alignments of 45 vertebrate genomes with hg19/GRCh37 human genome (08-Oct-2009)

Query Data
Protein or SNP identifier
Protein sequence
in FASTA format
Position
Substitution
Query description
Display advanced query options