PolyPhen-2 (Polymorphism Phenotyping v2) is a tool which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations. Please, use the form below to submit your query.
08-May-2011: PolyPhen-2 server has been updated to utilize version 2.1.0 of the software, protein sequences from UniProtKB/UniRef100 Release 2011_04 (05-Apr-2011), and structures from PDB/DSSP Snapshot 06-Apr-2011 (72,244 entries).
