PolyPhen-2 prediction of functional effects of human nsSNPs

PolyPhen-2 (Polymorphism Phenotyping v2) is a tool which predicts possible impact of an amino acid substitution on the structure and function of a human protein using straightforward physical and comparative considerations. Please, use the form below to submit your query.

21-Jun-2021: Server has been migrated to new hardware. Note, all queries were terminated and user sessions data discarded in the process, hence you will need to resubmit your query if affected. We aplogize for the inconvenience caused.

Query Data
Protein or SNP identifier
Protein sequence
in FASTA format
Query description
Display advanced query options