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Software and Services

We develop and maintain a variety of software and web services.

Functional Prediction of Genetic Variants

* PolyPhen-2 is a tool for predicting the effect of an amino acid substitution on protein structure and function, based on comparative genomics and experimentally determined protein structures. It is available as a web service, and can also be downloaded as a standalone application. * SCONE is a tool for predicting the effect of noncoding variation on regulatory sequences based on evolutionary conservation. It is available for download as a standalone application.

Tools for Mass Spectrometry and Proteomics

* EagleEye is a tool for filtering noise and background proteins from LC-MS/MS spectra. It is available as a web service. * MS-BLAST is a tool for searching protein sequences identified with tandem mass spectrometry against databases of protein sequences. It is available as a web service.