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members [2015/03/31 12:19]
dvuzman
members [2017/10/25 16:31]
dweghorn [Lab Members]
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-**[[ssunyaev@rics.bwh.harvard.edu|Shamil Sunyaev]]** is a Professor of Medicine at Harvard Medical School and a Research Geneticist at Brigham & Women’s Hospital. He is also an Associate Member at Broad Institute of MIT and Harvard. Shamil is a computational geneticist interested in many aspects of genetic variation from the evolutionary,​ functional and medical genetics perspectives. Population genetics of human deleterious alleles has been one of his major interests. He also develops computational and statistical methods for sequencing studies and methods that use comparative genomics and protein structure to predict the functional effect of mutations.+**[[ssunyaev@rics.bwh.harvard.edu|Shamil Sunyaev]]** is a Professor of Medicine ​and Biomedical Informatics ​at Harvard Medical School and a Research Geneticist at Brigham & Women’s Hospital. He holds a Distinguished Chair of Computational Genomics. He is also an Associate Member at Broad Institute of MIT and Harvard. Shamil is a computational geneticist interested in many aspects of genetic variation from the evolutionary,​ functional and medical genetics perspectives. Population genetics of human deleterious alleles has been one of his major interests. He also develops computational and statistical methods for sequencing studies and methods that use comparative genomics and protein structure to predict the functional effect of mutations.
  
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 **[[iadzhubey@rics.bwh.harvard.edu|Ivan Adzhubey]]** is an Instructor in Medicine at Harvard Medical School and an Associate Geneticist at Brigham and Women'​s Hospital. Ivan helps develop PolyPhen-2, a tool for annotating coding nonsynonymous SNPs, which includes a high quality multiple sequence alignment pipeline and probabilistic classifier based on machine-learning method that is optimized for high-throughput analysis of the next-generation sequencing data. **[[iadzhubey@rics.bwh.harvard.edu|Ivan Adzhubey]]** is an Instructor in Medicine at Harvard Medical School and an Associate Geneticist at Brigham and Women'​s Hospital. Ivan helps develop PolyPhen-2, a tool for annotating coding nonsynonymous SNPs, which includes a high quality multiple sequence alignment pipeline and probabilistic classifier based on machine-learning method that is optimized for high-throughput analysis of the next-generation sequencing data.
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-**[[cassa@mit.edu|Christopher Cassa]]** is an Instructor ​in Medicine at Harvard ​Medical School, an Associate Geneticist at Brigham ​and Women'​s Hospital, and a Lecturer at the Massachusetts Institute of TechnologyHis focus is on the clinical interpretation of whole genome sequence data for Mendelian disorders. Areas of focus include incomplete penetrance, detection of epistatic effects, ​and methods development for pathogenicity prediction using population data.+**[[akle@fas.harvard.edu|Sebastian Akle]]** is a PhD student ​in the Harvard ​Organismal ​and Evolutionary Biology program. He is interested in population geneticsstatistical genetics ​and gene mappingHe is currently designing a QTL mapping algorithm that uses next generation sequencing ​and bulk segregant analysis.
  
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-{{:dana.jpg?​nolink&​100 |}} +**[[dbalick@research.bwh.harvard.edu|Daniel Balick]]** earned his BSH in physics ​at Stanford ​and his PhD in theoretical physics at the University ​of California, Santa Barbara under the guidance of Boris Shraiman at the KITP.  Dan's work focuses on the mathematical modeling of non-equilibrium phenomena in population genetics and evolutionary dynamics. ​ Specifically,​ he is interested in the interaction between natural selection, stochastic drift, and mutation rate when one or more of these forces is explicitly time dependent. ​ Recent work focuses on inference of recessive selection via population bottlenecks,​ understanding population genetic constraints on the allelic architecture of complex traits, and the dynamics of mutation rate heterogeneity. ​ Resources relevant to Dan's research can be found [[http://genetics.bwh.harvard.edu/wiki/sunyaevlab/dbalick|here]].
-**[[dvuzman@research.bwh.harvard.edu|Dana Vuzman]]** is an Instructor ​in Medicine ​at Harvard Medical School ​and an Associate Director ​of [[http://www.brighamandwomens.org/Departments_and_Services/medicine/services/​genetics/​services/​genome_svs.aspx?​sub=0|Personal Genomics Consultation Service (PGCS)]]. She works collaboratively with clinical geneticists,​ computational biologists and other specialists at our institution,​ throughout the Harvard Medical affiliates, and throughout the world, to find new genetic causes for rare genetic phenotypes.+
  
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 +**[[cassa@mit.edu|Christopher Cassa]]** is an Instructor in Medicine at Harvard Medical School, an Associate Geneticist at Brigham and Women'​s Hospital, and a Lecturer at the Massachusetts Institute of Technology. His focus is on the clinical interpretation of whole genome sequence data for Mendelian disorders. Areas of focus include incomplete penetrance, detection of epistatic effects, and methods development for pathogenicity prediction using population data.
  
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-**[[dbalick@research.bwh.harvard.edu|Daniel Balick]]** earned his BSH in physics at Stanford and his PhD in theoretical physics at the University of California, Santa Barbara under the guidance of Boris Shraiman at the KITP.  Dan's work focuses on the mathematical modeling of non-equilibrium phenomena in population genetics and evolutionary dynamics. ​ Specifically,​ he is interested in the interaction between natural selection, stochastic drift, and mutation rate when one or more of these forces is explicitly time dependent. ​ Recent work focuses on inference of recessive selection via population bottlenecks,​ understanding population genetic constraints on the allelic architecture of complex traits, and the dynamics of mutation rate heterogeneity. 
  
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-**[[sgchun@partners.org|Sung Chun]]** is a postdoctoral fellow, and he is interested ​in understanding the genetic architecture of complex disease ​and natural selection acting on genetic variation underlying heritable disorders. His projects include development of a risk prediction model for myocardial infarction, identification of candidate causal variants underlying rare undiagnosed genetic disorder ​and evolution of monoallelic expression. +**[[sgchun@partners.org|Sung Chun]]** is an Instructor ​in Medicine at Harvard Medical School ​and an Associate Geneticist at Brigham ​and Women'​s HospitalHe received his PhD in Computational ​and Systems Biology at Washington University ​in St. Louis under the supervision ​of Justin Fay. He is interested in statistical genetics of complex disease ​and evolutionary genetics of adaptation ​and pleiotropyHis current projects include development ​of statistical ​test for shared ​genetic ​effect between autoimmune disease GWAS and blood eQTLgenetic risk prediction ​of myocardial infarction, and genetic analysis ​of cardiovascular co-morbidity
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-**[[http://​www.evolbio.mpg.de/​EvolutionaryImmunogenomics|Tobias Lenz]]** was a DFG-funded postdoctoral fellow ​in the lab and his research focused on the evolution of genetic diversity ​in the human major histocompatibility complex (MHC) and the evolutionary significance ​of individual MHC diversity. He is interested in the mechanisms that create genetic diversity in the MHC region as well as the selective constraints that shape and maintain the exceptional genetic diversity at MHC and particularly at Human Leukocyte Antigen (HLA) loci. +
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-**[[http://​www.broadinstitute.org/​~jhsul/​|Jae Hoon Sul]]** is a postdoctoral fellow, and he obtained his Ph.D. in computer science at University ​of California, Los Angeles. His research focuses on developing ​statistical ​methods in genetics such as correcting ​for population structure in GWASs, identifying rare variants involved in diseases, and detecting eQTLs from multiple tissues. He is also interested in understanding the genetic ​architecture of neurological disorders ​and participates in several GWASswhole-genome and exome sequencing projects as a statistical analyst.  +
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-**[[dweghorn@research.bwh.harvard.edu|Donate Weghorn]]** is a postdoctoral fellow who obtained her PhD in theoretical physics at the University ​of CologneGermany. Her research focuses on applying population genetics ​and statistical methods to data sets from systems undergoing molecular evolution. This involves elucidating the evolution ​of the human gut microbiome. Another focus of Donate'​s work is detecting how cancer tumors come into existence and are maintained, despite selective forces working against these processes.+
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-**[[akle@fas.harvard.edu|Sebastian Akle]]** is a PhD student in the Harvard Organismal and Evolutionary Biology program. He is interested in population genetics, statistical genetics and gene mapping. He is currently designing a QTL mapping algorithm that uses next generation sequencing and bulk segregant analysis. 
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-**[[dmjordan@fas.harvard.edu|Daniel Jordan]]** is a PhD student in the Harvard Biophysics program. He studies the problem of predicting the functional effects of genetic variation, primarily through the lens of the PolyPhen software. His major projects include investigating the effect of epistasis on prediction of variant effects, developing predictors for use in clinical genetic diagnostics,​ and developing a more accurate way to incorporate phylogenetic data into PolyPhen'​s predictions. 
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 **[[davidradke@fas.harvard.edu|David Radke]]** is a PhD student in the Biological and Biomedical Sciences (BBS) program at Harvard Medical School. He is interested broadly in human evolution and specifically in how genomic structural variants (such as CNVs and indels, among others) helped shape modern human uniqueness. He combines population genetics and comparative genomics to assess the role of structural variants in both modern human and archaic populations. **[[davidradke@fas.harvard.edu|David Radke]]** is a PhD student in the Biological and Biomedical Sciences (BBS) program at Harvard Medical School. He is interested broadly in human evolution and specifically in how genomic structural variants (such as CNVs and indels, among others) helped shape modern human uniqueness. He combines population genetics and comparative genomics to assess the role of structural variants in both modern human and archaic populations.
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 +**[[alicodendrochit@gmail.com|Vladmir Seplyarskiy]]** graduated from Moscow State University and did his PhD research in Georgii Bazykin'​s lab at IITP. Vladimir is interested in mutational patterns and underlying biological mechanisms. He is trying to measure DNA repair preferences by comparing mutational profiles between cancers with very specific deficiencies in repair or replication. Current projects also include characterization of sources for heritable mutations and investigation of evolution of mutation rates.
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 +**[[onuralp@broadinstitute.org|Onuralp Söylemez]]** is a postdoctoral research fellow. He obtained his PhD in biomedical sciences at Pompeu Fabra University, Spain. During his PhD, he studied the prevalence and role of allele interactions at the protein level in shaping fitness within natural populations and between species. His current research focuses on applying evolutionary and population genetics tools to gene and pathway discovery via diagnosis of patients with Mendelian disorders of unknown etiology. His primary research interests include the link between Mendelian disorders and multifactorial traits, statistical genetics of rare genetic diseases, and novel regulatory mechanisms of pleiotropy.
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 +**[[dweghorn@research.bwh.harvard.edu|Donate Weghorn]]** is a postdoctoral fellow who obtained her PhD in theoretical physics at the University of Cologne, Germany. Her research focuses on developing probabilistic models based on population genetics, with the particular aim of extracting selection signals. Donate'​s primary interest is in cancer, involving describing how cancer tumors come into existence and are maintained, despite selective forces working against these processes. Previous work includes inference of selection in the human germline, in the human gut microbiome, and on nucleosome formation.
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-{{:​karen.jpg?​nolink&​100 |}} +===== Former Lab Members =====
-**[[KBARRY6@partners.org|Karen Barry]]** is our lab administrator,​ who helps keep things running. ​+
  
 +Dana Vuzman (Postdoctoral fellow)\\ ​
 +Daniel Jordan (Graduate student)\\ ​
 +Jae-Hoon Sul (Postdoctoral fellow)\\ ​
 +Tobias Lenz (Postdoctoral fellow)\\ ​
 +Paz Polak (Postdoctoral fellow)\\ ​
 +Nina Stoletzki (Postdoctoral fellow)\\ ​
 +Ignaty Leshchiner (Postdoctoral fellow)\\ ​
 +David Nusinow (Postdoctoral fellow)\\ ​
 +Nathan Stitziel (Postdoctoral fellow)\\ ​
 +Adam Kiezun (Postdoctoral fellow)\\ ​
 +Alex Shpunt (Graduate student)\\ ​
 +Gregory Kryukov (Postdoctoral fellow)\\ ​
 +Victor Spirin (Postdoctoral fellow)\\ ​
 +Saurabh Asthana (Graduate student)\\ ​
 +Steffen Schmidt (Postdoctoral fellow)