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jlim [2016/11/18 16:19]
schun [How to run JLIM on your data]
jlim [2017/02/25 00:07]
schun [Joint Likelihood Mapping (JLIM)]
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 ====== Joint Likelihood Mapping (JLIM) ====== ====== Joint Likelihood Mapping (JLIM) ======
  
-JLIM is a cross-trait test of shared causal effect, which is described in Chun et al. ([[http://biorxiv.org/content/early/2016/05/12/053165|BioRxiv]]). JLIM tests whether two traits – main and secondary – are driven by shared causal effect or not. Typically, the main trait is a large GWAS study, and secondary trait can be an expression Quantitative Trait Loci (eQTL) association study. For main trait, JLIM takes only summary-level association statistics, but for secondary trait, it requires genotype-level data to generate permutation-based null distribution.+JLIM is a cross-trait test of shared causal effect, which is described in [[http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3795.html|Chun et al. 2017]]. JLIM tests whether two traits – main and secondary – are driven by shared causal effect or not. Typically, the main trait is a large GWAS study, and secondary trait can be an expression Quantitative Trait Loci (eQTL) association study. For main trait, JLIM takes only summary-level association statistics, but for secondary trait, it requires genotype-level data to generate permutation-based null distribution. ​JLIM is simultaneously released at [[https://​github.com/​cotsapaslab/​jlim|Cotsapas lab github]] and Sunyaev lab website.  
 +===== Download ===== 
 +{{ :​jlim-1.0.2.tar.gz | JLIM release v1.0.2 }}
  
 ===== How to install ===== ===== How to install =====