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DANIEL BALICK'S SOFTWARE AND RESOURCES


This page contains links to various software resources associated with our research. Feel free to email dbalick@research.bwh.harvard.edu if you have any questions, comments, or suggestions.

MUTATIONAL BURDEN SIMULATOR


written by David Reich

SIMULATION WITH SELECTION, DOMINANCE, AND NON-EQUILIBRIUM DEMOGRAPHY

How does a population bottleneck impact the mutation burden under differing dominance and selection coefficients?

Below is the code for burden_sim, a simulation of the mutation burden for two populations after a split, as described in Balick, et. al. Response to a population bottleneck can be used to infer recessive selection (2013 preprint available here: biorxiv,currently under review). This simulation was also used in Do, et. al. No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans (Nature Genetics 2015).

README

CODE (written in C)

COMPILED CODE