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dbalick [2015/06/05 01:54]
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dbalick [2015/09/20 01:41]
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 ======== ​ DANIEL BALICK'​S SOFTWARE AND RESOURCES ======== ======== ​ DANIEL BALICK'​S SOFTWARE AND RESOURCES ========
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 written by David Reich written by David Reich
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-====  ​SIMULATION WITH SELECTION, DOMINANCE, AND NON-EQUILIBRIUM DEMOGRAPHY  ​====+==== Simulating selection and dominance in a non-equilibrium demography ​====
  
    
 How does a population bottleneck impact the mutation burden under differing dominance and selection coefficients?​ How does a population bottleneck impact the mutation burden under differing dominance and selection coefficients?​
  
-Below is the code for **burden_sim**,​ a simulation of the mutation burden for two populations after a split, as described in Balick, et al. //Response to a population bottleneck can be used to infer recessive selection// (2013 preprint available here: [[http://biorxiv.org/content/early/2014/​03/​21/​003491biorxiv]],currently under review).   This simulation was also used in Do, et al. //No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans// ([[http://​www.nature.com/​ng/​journal/​v47/​n2/​abs/​ng.3186.html|Nature Genetics 2015]]).+Below is the code for **burden_sim**,​ a simulation of the mutation burden for two populations after a split, as described in Balick, et al.//Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck// ([[http://journals.plos.org/plosgenetics/article?​id=10.1371/journal.pgen.1005436|PLOS Genetics 2015]]).   This simulation was also used in Do, et al.//No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans// ([[http://​www.nature.com/​ng/​journal/​v47/​n2/​abs/​ng.3186.html|Nature Genetics 2015]]).
  
 ====  README ==== ====  README ====
  
-  * {{README_burden_sim.pdf|README}}+  * {{README_burden_sim_v0.pdf|README}}
  
  
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   * Burden simulation for Gravel demography: ​ {{burden_sim_Gravel.zip}}   * Burden simulation for Gravel demography: ​ {{burden_sim_Gravel.zip}}
   * Burden simulation for Tennessen demography: ​ {{burden_sim_Tennessen.zip}}   * Burden simulation for Tennessen demography: ​ {{burden_sim_Tennessen.zip}}
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 +Note:  This page is managed by DJB and does not necessarily reflect the Sunyaev lab as a whole. ​
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