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--- dbalick [2015/06/05 01:13]
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-========  Daniel Balick's software and resources page ========
+{{:evolution_laptop.jpg?nolink&670|}}
+========  DANIEL BALICK'S SOFTWARE AND RESOURCES ========
+----
 This page contains links to various software resources associated with our research.  Feel free to email [[dbalick@research.bwh.harvard.edu]] if you have any questions, comments, or suggestions.
-=====  Selection, dominance, and demographic history =====
-Below is the code for **burden_sim**, a simulation of the mutation burden for two populations after a split, as described in Balick, et. al. "Response to a population bottleneck can be used to infer recessive selection" (2013 preprint available here: [[http://biorxiv.org/content/early/2014/03/21/003491| biorxiv]],currently under review).   This simulation was also used in Do, et. al. "No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans" ([[No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans|Nature Genetics 2015]]).
+=====  MUTATIONAL BURDEN SIMULATOR =====
+----
+written by David Reich
+====  SIMULATION WITH SELECTION, DOMINANCE, AND NON-EQUILIBRIUM DEMOGRAPHY  ====
+How does a population bottleneck impact the mutation burden under differing dominance and selection coefficients?
+Below is the code for **burden_sim**, a simulation of the mutation burden for two populations after a split, as described in Balick, et al., //Response to a population bottleneck can be used to infer recessive selection// (2013 preprint available here: [[http://biorxiv.org/content/early/2014/03/21/003491| biorxiv]],currently under review).   This simulation was also used in Do, et al., //No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans// ([[http://www.nature.com/ng/journal/v47/n2/abs/ng.3186.html|Nature Genetics 2015]]).
 ====  README ====
-{{README_burden_sim.pdf|README}}
+  * {{README_burden_sim.pdf|README}}
 ====  CODE (written in C) ====
-{{burden_sim_code.zip}}
+  * {{burden_sim_code.zip}}
 ====  COMPILED CODE ====
-Burden simulation for simple (square) bottleneck:  {{burden_sim_SimpleBN.zip}}
+  * Burden simulation for simple (square) bottleneck:  {{burden_sim_SimpleBN.zip}}
+  * Burden simulation for Gravel demography:  {{burden_sim_Gravel.zip}}
-Burden simulation for Gravel demography:  {{burden_sim_Gravel.zip}}
+  * Burden simulation for Tennessen demography:  {{burden_sim_Tennessen.zip}}
-Burden simulation for Tennessen demography:  {{burden_sim_Tennessen.zip}}