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cbase_about [2017/10/29 22:11]
dweghorn [Cancer Bayesian Selection Estimation (CBaSE)]
cbase_about [2017/10/29 22:13]
dweghorn
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-====== ​Cancer Bayesian Selection Estimation (CBaSE) ​======+====== ​In a nutshell ​======
  
 **CBaSE**, the method described in [[paper_link|Weghorn & Sunyaev (2017)]], is built around a hierarchical model framework, which aims to estimate gene-specific background substitution rates. It does so based solely on the input somatic mutation data, without the need for knowledge of external mutation rate covariates. The results are gene-specific estimates of positive and negative selection, respectively measuring excess or deficit of nonsynonymous mutations compared to the expectation under neutral evolution. **CBaSE**, the method described in [[paper_link|Weghorn & Sunyaev (2017)]], is built around a hierarchical model framework, which aims to estimate gene-specific background substitution rates. It does so based solely on the input somatic mutation data, without the need for knowledge of external mutation rate covariates. The results are gene-specific estimates of positive and negative selection, respectively measuring excess or deficit of nonsynonymous mutations compared to the expectation under neutral evolution.
  
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