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cbase_about [2017/10/29 21:52]
dweghorn created
cbase_about [2017/10/29 22:17]
dweghorn [In a nutshell]
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-====== Cancer Bayesian Selection Estimation (CBaSE) ======+===== In a nutshell ​=====
  
-**CBaSE**, the method described in [[paper_link|Weghorn & Sunyaev (2017)]], is built around a hierarchical model framework, which aims to estimate the gene-specific background substitution ​rate. It does so based solely on the input somatic mutation data, without the need for knowledge of external mutation rate covariates. ​The results are gene-specific ​estimates ​of positive and negative selectionrespectively measuring ​excess or deficit of nonsynonymous ​mutations ​compared to the expectation under neutral evolution.+**CBaSE**, the method described in [[paper_link|Weghorn & Sunyaev (2017)]], is built around a hierarchical model framework, which estimates ​gene-specific background substitution ​rates. It does so based solely on the input somatic mutation data, without the need for knowledge of external mutation rate covariates. ​Using the substitution rate estimates ​together with a nucleotide context-dependent mutation matrix, excess or deficit of nonsynonymous ​substitutions can be compared to the expectation under neutral evolution. The results are gene-specific estimates of positive and negative selection.
  
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