Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Next revision Both sides next revision
cbase_about [2017/10/29 21:52]
dweghorn created
cbase_about [2017/10/29 22:11]
dweghorn [Cancer Bayesian Selection Estimation (CBaSE)]
Line 2: Line 2:
 ====== Cancer Bayesian Selection Estimation (CBaSE) ====== ====== Cancer Bayesian Selection Estimation (CBaSE) ======
  
-**CBaSE**, the method described in [[paper_link|Weghorn & Sunyaev (2017)]], is built around a hierarchical model framework, which aims to estimate ​the gene-specific background substitution ​rate. It does so based solely on the input somatic mutation data, without the need for knowledge of external mutation rate covariates. The results are gene-specific estimates of positive and negative selection, respectively measuring excess or deficit of nonsynonymous mutations compared to the expectation under neutral evolution.+**CBaSE**, the method described in [[paper_link|Weghorn & Sunyaev (2017)]], is built around a hierarchical model framework, which aims to estimate gene-specific background substitution ​rates. It does so based solely on the input somatic mutation data, without the need for knowledge of external mutation rate covariates. The results are gene-specific estimates of positive and negative selection, respectively measuring excess or deficit of nonsynonymous mutations compared to the expectation under neutral evolution.
  
 Please cite Please cite