This page contains links to various software resources associated with our research. Feel free to email email@example.com if you have any questions, comments, or suggestions.
written by David Reich
How does a population bottleneck impact the mutation burden under differing dominance and selection coefficients?
Below is the code for burden_sim, a simulation of the mutation burden for two populations after a split, as described in Balick, et al., Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck (PLOS Genetics 2015). This simulation was also used in Do, et al., No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans (Nature Genetics 2015).
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