The Sunyaev Lab
We are a computational genomics laboratory at the Genetics Division of Brigham & Women's Hospital and Harvard Medical School. The primary focus of research in the lab is on genetic variation, including the biology and evolution of mutation, the effect of variation on molecular function and structure, population genetics as a lens on evolution, and the maintenance and allelic architecture of complex traits. We develop computational and statistical methods for sequencing studies. We also have projects in cancer genomics, metagenomics, and applied human genetics. The lab encompasses a wide range of skills, backgrounds, and interests spanning these topics.

Shamil R. Sunyaev, Professor
Harvard Medical School, Department of Medicine
Brigham and Women's Hospital, Division of Genetics


We are involved in the following graduate programs:

Shamil teaches a course on Computational and Functional Genomics for Predicting Gene Function (Biophysics205) with Martha Bulyk and Suzanne Gaudet; and a course on Quantitative Genomics (HST.508/Biophysics170) with Leonid Mirny at MIT.

The lab is involved in the Medical and Population Genetics Program at the Broad Institute of MIT and Harvard and the Boston Evolutionary Genomics Supergroup.