====== Downloads ======

Downloadable material.

===== Software =====

** Licensing **

The software provided herein is free for academic instruction and research use only. Commercial licenses are available to legal entities, including companies and organizations (both for-profit and non-profit), requiring the software for general commercial use. To obtain a commercial license please, contact us via [[ivan_adzhubey@hms.harvard.edu|e-mail]].

** Disclaimer **

This software is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. The code should not be modified and/or redistributed without the permission of the authors.

===== Source Code =====

^   Item                             ^ File(s) ^
| PolyPhen-2 standalone source code, see INSTALL\\ file included for installation instructions  | {{polyphen-2.2.3r408.tar.gz}}  |

===== Databases and Datasets =====

^   Item                             ^ File(s)   ^
| PolyPhen-2 bundled databases & datasets  | [[https://dataverse.harvard.edu/dataset.xhtml?persistentId=doi:10.7910/DVN/1VAZ6P|Harvard Dataverse]]  |

===== Extra Datasets =====

^  Item                          ^ File(s)                                 ^
| HumDiv & HumVar training sets  | [[http://genetics.bwh.harvard.edu/downloads/pph2/training/|README]]  |
| Whole human exome sequence space annotations  | [[http://genetics.bwh.harvard.edu/downloads/pph2/whess/|README]]  |

===== Publications =====

^  Item                 ^  Description  ^ File(s)   ^
| Nat Methods **7**, 248-9 (2010)  |  PolyPhen-2 paper  | {{nmeth0410-248.pdf|PDF}} {{nmeth0410-248-s1.pdf|Supplement}}  |
| Nucleic Acids Res **30**, 3894-900 (2002)  |  PolyPhen paper  | {{nar-2002-3894.pdf|PDF}}  |
| Protein Eng **12**, 387-94 (1999)  |  PSIC paper  | {{peds-1999-387.pdf|PDF}}  |