http://genetics.bwh.harvard.edu/pph2/dokuwiki/ 2012-05-16T05:53:20-04:00 http://genetics.bwh.harvard.edu/pph2/dokuwiki/ http://genetics.bwh.harvard.edu/pph2/dokuwiki/lib/tpl/dokucms/images/favicon.ico text/html 2012-04-25T22:07:15-04:00 ivan http://genetics.bwh.harvard.edu/pph2/dokuwiki/downloads?rev=1335406035&do=diff Downloadable material. Software Licensing The software provided herein is free for academic instruction and research use only. Commercial licenses are available to legal entities, including companies and organizations (both for-profit and non-profit), requiring the software for general commercial use. To obtain a commercial license please, contact us via e-mail. text/html 2012-04-25T22:07:01-04:00 ivan http://genetics.bwh.harvard.edu/pph2/dokuwiki/?image=polyphen-2.2.2r397.tar.gz&ns=&rev=1335406021&tab_details=history&mediado=diff&do=media text/html 2012-03-08T15:08:37-04:00 ivan http://genetics.bwh.harvard.edu/pph2/dokuwiki/start?rev=1331237317&do=diff PolyPhen-2 (Polymorphism Phenotyping v2) is a software tool which predicts possible impact of amino acid substitutions on the structure and function of human proteins using straightforward physical and evolutionary comparative considerations. Explore navigation menu on the left to find out more About PolyPhen-2, consult the Documentation (work in progress), or Download standalone software, datasets and publications. text/html 2012-03-08T14:58:25-04:00 ivan http://genetics.bwh.harvard.edu/pph2/dokuwiki/news?rev=1331236705&do=diff Mar 08, 2012 WHESS.db option added to the PolyPhen-2 web interface. Feb 23, 2012 PolyPhen-2 build r394 was released which fixes a number of bugs reported since the initial v2.2.2 release. ChangeLog: * Added missing MultiZ alignments for hg18 UCSC genome assembly version * Corrected substitution profile scores for hg19 MultiZ alignments, which were calculated with the wrong PSIC parameters * Updated classifier models to reflect the changes in distribution of PSIC profile scores caused… text/html 2011-10-21T21:04:07-04:00 ivan http://genetics.bwh.harvard.edu/pph2/dokuwiki/?image=polyphen-2.1.0r367a.tar.gz&ns=&rev=1319245447&tab_details=history&mediado=diff&do=media