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| + | ====== About ====== | ||
| + | **PolyPhen-2** is a new development of the **PolyPhen** tool for annotating coding nonsynonymous SNPs. Some of the highlights of the new version are: | ||
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| + | * High quality multiple sequence alignment pipeline | ||
| + | * Probabilistic classifier based on machine-learning method | ||
| + | * Optimized for high-throughput analysis of the next-generation sequencing data | ||
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| + | == Please cite: == | ||
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| + | * Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. Nat Methods **7**(4): | ||
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| + | == Other References: == | ||
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| + | - Adzhubei I, Jordan DM, Sunyaev SR. Predicting functional effect of human missense mutations using PolyPhen-2. Curr Protoc Hum Genet, Chapter 7:Unit7.20 (2013). [[http:// | ||
| + | - Ramensky V, Bork P, Sunyaev S. Human non-synonymous SNPs: server and survey. Nucleic Acids Res **30**(17): | ||
| + | - Sunyaev SR, Eisenhaber F, Rodchenkov IV, Eisenhaber B, Tumanyan VG, Kuznetsov EN. PSIC: profile extraction from sequence alignments with position-specific counts of independent observations. Protein Eng **12**(5): | ||
about.txt · Last modified: 2016/01/05 18:03 by 127.0.0.1