| I.PolyPhen SNP data collection | |||
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The developed prediction method
enabled the analysis of all human non-synonymous SNPs publicly available via
dbSNP database.
This gave rise to a data collection of nsSNPs with predicted impact on
protein structure and function.
All human SNPs from dbSNP build 126, were mapped to known human proteins. This resulted in 76,434 nsSNPs (54,573 unique) that were analysed by PolyPhen and comprise our data collection. You can download complete dataset of PolyPhen predictions. Alternatively, you can: If you use the above data, please cite:
Human non-synonymous SNPs: server and survey.
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See also: | ||
| I.1.Data collection statistics | |||
Statistics of PolyPhen predictions for dbSNP build 126Total human refSNP entries in dbSNP...........11,961,761 54,573 unique ns rs entries in 21,405 sequences 76,434 entries in total ======================= 1,191 unknown...............1.6% 49,795 benign...............65.2% 14,187 possibly damaging....18.6% 11,174 probably damaging....14.6% | |||