Bork Group Sunyaev Lab
PolyPhen report
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refSNP Predictions found for proteins:
rs5949 P12429

 
Query
Acc number Position AA1 AA2 Description
P12429 251 P L Annexin A3 (Annexin III) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III) (35-alpha calcimedin) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase). LENGTH: 323 AA

Prediction
This variant is predicted to be probably damaging
Prediction Available data Prediction basis Substitution effect Prediction data
probably
damaging
FT
alignment
structure
alignment N/A PSIC score difference: 2.631
Remarks
Closest contact with ligand: K21, distance 5.865
Hydrophobicity change at buried site; normed accessibility: 0.14, hydrophobicity change: 1.07

Details
Sequence features of the substitution site
Region Site Feature table Critical sites
N/A N/A show FT fields for P12429 N/A
PSIC profile scores for two amino acid variants
Score1 Score2 |Score1-Score2| Observations Diagnostics Multiple alignment around substitution position
+1.735 -0.896 2.631 52 precomputed Sequences:  Flanks:  
Mapping of the substitution site to known protein 3D structures
Database Initial number of structures Number of structures
PQS 141 22

Num ID   Res AA E-value Len Ide Gaps Params Cont PDB TITLE
1 1axn _ 252 P 0.0e+00 322 1.00 Params   N/A
2 1aii _ 252 P 0.0e+00 322 1.00     N/A
3 1m9i A 253 P 7.1e-89 316 0.52     OF ANNEXIN VI
4 1avc _ 601 P 5.6e-78 313 0.50 9     N/A
5 1hak_2 C 248 P 8.7e-87 315 0.50     INHIBITOR
6 1hak_2 B 248 P 8.7e-87 315 0.50     INHIBITOR
7 1hak_2 A 248 P 8.7e-87 315 0.50     INHIBITOR
8 1hak_1 C 248 P 8.7e-87 315 0.50   Het INHIBITOR
9 1hak_1 B 248 P 8.7e-87 315 0.50   Het INHIBITOR
10 1hak_1 A 248 P 8.7e-87 315 0.50   Het INHIBITOR
11 1avh_2 B 248 P 8.7e-87 315 0.50     N/A
12 1avh_1 A 248 P 8.7e-87 315 0.50     N/A
13 1anw_2 B 248 P 8.7e-87 315 0.50     N/A
14 1anw_1 A 248 P 8.7e-87 315 0.50     N/A
15 1avr _ 248 P 4.3e-86 314 0.50     N/A
16 1ala _ 248 P 4.3e-86 313 0.50     N/A
17 1anx_3 C 248 P 1.3e-85 312 0.50     N/A
18 1anx_2 B 248 P 1.3e-85 312 0.50     N/A
19 1anx_1 A 248 P 1.3e-85 312 0.50     N/A
20 1hvd _ 248 P 8.1e-85 311 0.50     N/A
21 1hve _ 248 P 1.4e-84 311 0.50     N/A
22 1hvf _ 248 P 1.8e-84 311 0.50     N/A

Structural parameters
Num ID   Res SecStr Acc Acc Normed dPropens (Phi, Psi) Map Region dVol Normed B-factor
1 1axn _ 252 H 18 0.14 1.07 (-57.3, -35.6) A 55 -0.99

Contacts
Num ID   Res Heteroatoms Interchain Critical sites
  8 1hak_1 C 248 0.000
   
  9 1hak_1 B 248 901B K21 5.865
   
  10 1hak_1 A 248 901A K21 5.865