PolyPhen: results for dnSNP rs671

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refSNP	Predictions found for proteins:
rs671	P05091

Query

Acc number	Position	AA₁	AA₂	Description
P05091	504	E	K	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). LENGTH: 517 AA

Prediction

This variant is predicted to be possibly damaging

Prediction	Available data	Prediction basis	Substitution effect	Prediction data
possibly damaging	FT alignment structure	structure	1.1.1: structural effect, buried site, hydrophobicity Hydrophobicity change at buried site	PSIC score difference: 1.078 normed accessibility: 0.07 hydrophobicity change: 1.3
Remarks
Closest contact with ligand: GAI, distance 4.364
Closest contact with other chains: ARG 475D, distance 2.719 Å
Charge change at buried site: substitution E -> K, normed accessibility: 0.07

Details

Sequence features of the substitution site

Region	Site	Feature table	Critical sites
N/A	N/A	show FT fields for P05091	285, 319

PSIC profile scores for two amino acid variants

Score1	Score2	\|Score1-Score2\|	Observations	Diagnostics	Multiple alignment around substitution position
+1.490	+0.412	1.078	127	precomputed	Sequences: Flanks:

Mapping of the substitution site to known protein 3D structures

Database	Initial number of structures	Number of structures
PQS	155	90

Num	ID		Res	AA	E-value	Len	Ide	Gaps	Params	Cont	PDB TITLE
1	1o01_1	C	487	E	0.0e+00	495	1.00		Params	Het Chain	CROTONALDEHYDE, NAD(H) AND MG2+
2	1o05_2	H	487	E	0.0e+00	494	1.00			Chain	APO FORM OF HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE
3	1o05_2	G	487	E	0.0e+00	494	1.00			Chain	APO FORM OF HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE
4	1o05_2	F	487	E	0.0e+00	494	1.00			Chain	APO FORM OF HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE
5	1o05_2	E	487	E	0.0e+00	494	1.00			Chain	APO FORM OF HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE
6	1o05_1	D	487	E	0.0e+00	494	1.00			Chain	APO FORM OF HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE
7	1o05_1	C	487	E	0.0e+00	494	1.00			Chain	APO FORM OF HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE
8	1o05_1	B	487	E	0.0e+00	494	1.00			Chain	APO FORM OF HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE
9	1o05_1	A	487	E	0.0e+00	494	1.00			Chain	APO FORM OF HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE
10	1o02_2	H	487	E	0.0e+00	494	1.00			Het Chain	NADH IN THE PRESENCE OF MG2+
11	1o02_2	G	487	E	0.0e+00	494	1.00			Het Chain	NADH IN THE PRESENCE OF MG2+
12	1o02_2	F	487	E	0.0e+00	494	1.00			Het Chain	NADH IN THE PRESENCE OF MG2+
13	1o02_2	E	487	E	0.0e+00	494	1.00			Het Chain	NADH IN THE PRESENCE OF MG2+
14	1o02_1	D	487	E	0.0e+00	494	1.00			Het Chain	NADH IN THE PRESENCE OF MG2+
15	1o02_1	C	487	E	0.0e+00	494	1.00			Het Chain	NADH IN THE PRESENCE OF MG2+
16	1o02_1	B	487	E	0.0e+00	494	1.00			Het Chain	NADH IN THE PRESENCE OF MG2+
17	1o02_1	A	487	E	0.0e+00	494	1.00			Het Chain	NADH IN THE PRESENCE OF MG2+
18	1o01_2	H	487	E	0.0e+00	494	1.00			Het Chain	CROTONALDEHYDE, NAD(H) AND MG2+
19	1o01_2	G	487	E	0.0e+00	494	1.00			Het Chain	CROTONALDEHYDE, NAD(H) AND MG2+
20	1o01_2	F	487	E	0.0e+00	494	1.00			Het Chain	CROTONALDEHYDE, NAD(H) AND MG2+
21	1o01_2	E	487	E	0.0e+00	494	1.00			Het Chain	CROTONALDEHYDE, NAD(H) AND MG2+
22	1o01_1	D	487	E	0.0e+00	494	1.00			Het Chain	CROTONALDEHYDE, NAD(H) AND MG2+
23	1o01_1	B	487	E	0.0e+00	494	1.00			Het Chain	CROTONALDEHYDE, NAD(H) AND MG2+
24	1o01_1	A	487	E	0.0e+00	494	1.00			Het Chain	CROTONALDEHYDE, NAD(H) AND MG2+
25	1o00_2	H	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MG2+ SHOWING DUAL NAD(H) CONFORMATIONS
26	1o00_2	G	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MG2+ SHOWING DUAL NAD(H) CONFORMATIONS
27	1o00_2	F	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MG2+ SHOWING DUAL NAD(H) CONFORMATIONS
28	1o00_2	E	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MG2+ SHOWING DUAL NAD(H) CONFORMATIONS
29	1o00_1	D	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MG2+ SHOWING DUAL NAD(H) CONFORMATIONS
30	1o00_1	C	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MG2+ SHOWING DUAL NAD(H) CONFORMATIONS
31	1o00_1	B	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MG2+ SHOWING DUAL NAD(H) CONFORMATIONS
32	1o00_1	A	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MG2+ SHOWING DUAL NAD(H) CONFORMATIONS
33	1nzz_2	H	487	E	0.0e+00	494	1.00			Chain	NADH IN THE PRESENCE OF LOW MG2+
34	1nzz_2	G	487	E	0.0e+00	494	1.00			Chain	NADH IN THE PRESENCE OF LOW MG2+
35	1nzz_2	F	487	E	0.0e+00	494	1.00			Chain	NADH IN THE PRESENCE OF LOW MG2+
36	1nzz_2	E	487	E	0.0e+00	494	1.00			Chain	NADH IN THE PRESENCE OF LOW MG2+
37	1nzz_1	D	487	E	0.0e+00	494	1.00			Chain	NADH IN THE PRESENCE OF LOW MG2+
38	1nzz_1	C	487	E	0.0e+00	494	1.00			Chain	NADH IN THE PRESENCE OF LOW MG2+
39	1nzz_1	B	487	E	0.0e+00	494	1.00			Chain	NADH IN THE PRESENCE OF LOW MG2+
40	1nzz_1	A	487	E	0.0e+00	494	1.00			Chain	NADH IN THE PRESENCE OF LOW MG2+
41	1nzx_2	H	487	E	0.0e+00	494	1.00			Chain	NAD+ IN THE PRESENCE OF LOW MG2+
42	1nzx_2	G	487	E	0.0e+00	494	1.00			Chain	NAD+ IN THE PRESENCE OF LOW MG2+
43	1nzx_2	F	487	E	0.0e+00	494	1.00			Chain	NAD+ IN THE PRESENCE OF LOW MG2+
44	1nzx_2	E	487	E	0.0e+00	494	1.00			Chain	NAD+ IN THE PRESENCE OF LOW MG2+
45	1nzx_1	D	487	E	0.0e+00	494	1.00			Chain	NAD+ IN THE PRESENCE OF LOW MG2+
46	1nzx_1	C	487	E	0.0e+00	494	1.00			Chain	NAD+ IN THE PRESENCE OF LOW MG2+
47	1nzx_1	B	487	E	0.0e+00	494	1.00			Chain	NAD+ IN THE PRESENCE OF LOW MG2+
48	1nzx_1	A	487	E	0.0e+00	494	1.00			Chain	NAD+ IN THE PRESENCE OF LOW MG2+
49	1cw3	H	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MN2+
50	1cw3	G	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MN2+
51	1cw3	F	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MN2+
52	1cw3	E	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MN2+
53	1cw3	D	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MN2+
54	1cw3	C	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MN2+
55	1cw3	B	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MN2+
56	1cw3	A	487	E	0.0e+00	494	1.00			Chain	NAD+ AND MN2+
57	1o04_2	H	487	E	0.0e+00	494	1.00			Het Chain	DEHYDROGENASE COMPLEXED WITH NAD+ AND MG2+
58	1o04_2	G	487	E	0.0e+00	494	1.00			Het Chain	DEHYDROGENASE COMPLEXED WITH NAD+ AND MG2+
59	1o04_2	F	487	E	0.0e+00	494	1.00			Het Chain	DEHYDROGENASE COMPLEXED WITH NAD+ AND MG2+
60	1o04_2	E	487	E	0.0e+00	494	1.00			Het Chain	DEHYDROGENASE COMPLEXED WITH NAD+ AND MG2+
61	1o04_1	D	487	E	0.0e+00	494	1.00			Het Chain	DEHYDROGENASE COMPLEXED WITH NAD+ AND MG2+
62	1o04_1	C	487	E	0.0e+00	494	1.00			Het Chain	DEHYDROGENASE COMPLEXED WITH NAD+ AND MG2+
63	1o04_1	B	487	E	0.0e+00	494	1.00			Het Chain	DEHYDROGENASE COMPLEXED WITH NAD+ AND MG2+
64	1o04_1	A	487	E	0.0e+00	494	1.00			Het Chain	DEHYDROGENASE COMPLEXED WITH NAD+ AND MG2+
65	1nzw_2	H	487	E	0.0e+00	494	1.00			Chain	DEHYDROGENASE COMPLEXED WITH NADH AND MG2+
66	1nzw_2	G	487	E	0.0e+00	494	1.00			Chain	DEHYDROGENASE COMPLEXED WITH NADH AND MG2+
67	1nzw_2	F	487	E	0.0e+00	494	1.00			Chain	DEHYDROGENASE COMPLEXED WITH NADH AND MG2+
68	1nzw_2	E	487	E	0.0e+00	494	1.00			Chain	DEHYDROGENASE COMPLEXED WITH NADH AND MG2+
69	1nzw_1	D	487	E	0.0e+00	494	1.00			Chain	DEHYDROGENASE COMPLEXED WITH NADH AND MG2+
70	1nzw_1	C	487	E	0.0e+00	494	1.00			Chain	DEHYDROGENASE COMPLEXED WITH NADH AND MG2+
71	1nzw_1	B	487	E	0.0e+00	494	1.00			Chain	DEHYDROGENASE COMPLEXED WITH NADH AND MG2+
72	1nzw_1	A	487	E	0.0e+00	494	1.00			Chain	DEHYDROGENASE COMPLEXED WITH NADH AND MG2+
73	1ag8	D	487	E	0.0e+00	493	0.94			Chain	ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA
74	1ag8	C	487	E	0.0e+00	493	0.94			Chain	ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA
75	1ag8	B	487	E	0.0e+00	493	0.94			Chain	ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA
76	1ag8	A	487	E	0.0e+00	493	0.94			Chain	ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA
77	1a4z	D	487	E	0.0e+00	493	0.94			Chain	NAD (REDUCED) AND SAMARIUM (III)
78	1a4z	C	487	E	0.0e+00	493	0.94			Chain	NAD (REDUCED) AND SAMARIUM (III)
79	1a4z	B	487	E	0.0e+00	493	0.94			Chain	NAD (REDUCED) AND SAMARIUM (III)
80	1a4z	A	487	E	0.0e+00	493	0.94			Chain	NAD (REDUCED) AND SAMARIUM (III)
81	1bxs	D	487	E	0.0e+00	493	0.68			Chain	SHEEP LIVER CLASS 1 ALDEHYDE DEHYDROGENASE WITH NAD BOUND
82	1bxs	C	487	E	0.0e+00	493	0.68			Chain	SHEEP LIVER CLASS 1 ALDEHYDE DEHYDROGENASE WITH NAD BOUND
83	1bxs	B	487	E	0.0e+00	493	0.68			Chain	SHEEP LIVER CLASS 1 ALDEHYDE DEHYDROGENASE WITH NAD BOUND
84	1bxs	A	487	E	0.0e+00	493	0.68			Chain	SHEEP LIVER CLASS 1 ALDEHYDE DEHYDROGENASE WITH NAD BOUND
85	1bi9	D	487	E	0.0e+00	498	0.67	17		Chain	RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND
86	1bi9	C	487	E	0.0e+00	498	0.67	19			RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND
87	1o9j	D	487	E	0.0e+00	493	0.66			Chain	THE X-RAY CRYSTAL STRUCTURE OF ETA-CRYSTALLIN
88	1o9j	C	487	E	0.0e+00	493	0.66			Chain	THE X-RAY CRYSTAL STRUCTURE OF ETA-CRYSTALLIN
89	1o9j	B	487	E	0.0e+00	493	0.66			Chain	THE X-RAY CRYSTAL STRUCTURE OF ETA-CRYSTALLIN
90	1o9j	A	487	E	0.0e+00	493	0.66			Chain	THE X-RAY CRYSTAL STRUCTURE OF ETA-CRYSTALLIN

Structural parameters

Num	ID		Res	SecStr	Acc	Acc Normed	dPropens	(Phi, Psi)	Map Region	dVol	Normed B-factor
1	1o01_1	C	487	E	14	0.07	1.3	(-114.3, 122.8)	B	30	-0.31

Contacts

Num	ID		Res	Heteroatoms	Interchain
1	1o01_1	C	487	`4803C GAI 4.681Å`	`467D GLY 3.339Å` `468D TYR 3.483Å` `469D LYS 5.430Å` `472D GLY 5.304Å` `473D SER 5.530Å` `474D GLY 5.395Å` `475D ARG 2.890Å`
2	1o05_2	H	487		`467G GLY 3.386Å` `468G TYR 3.506Å` `469G LYS 5.528Å` `472G GLY 5.318Å` `473G SER 5.421Å` `474G GLY 5.326Å` `475G ARG 2.886Å`
3	1o05_2	G	487		`467H GLY 3.356Å` `468H TYR 3.548Å` `469H LYS 5.499Å` `472H GLY 5.424Å` `473H SER 5.649Å` `474H GLY 5.457Å` `475H ARG 2.972Å`
4	1o05_2	F	487		`467E GLY 3.468Å` `468E TYR 3.431Å` `469E LYS 5.390Å` `472E GLY 5.397Å` `473E SER 5.614Å` `474E GLY 5.503Å` `475E ARG 2.913Å`
5	1o05_2	E	487		`467F GLY 3.458Å` `468F TYR 3.451Å` `469F LYS 5.567Å` `472F GLY 5.377Å` `473F SER 5.629Å` `474F GLY 5.469Å` `475F ARG 2.941Å`
6	1o05_1	D	487		`467C GLY 3.584Å` `468C TYR 3.554Å` `469C LYS 5.753Å` `472C GLY 5.470Å` `473C SER 5.579Å` `474C GLY 5.323Å` `475C ARG 2.860Å`
7	1o05_1	C	487		`467D GLY 3.655Å` `468D TYR 3.461Å` `469D LYS 5.561Å` `472D GLY 5.520Å` `473D SER 5.525Å` `474D GLY 5.322Å` `475D ARG 2.944Å`
8	1o05_1	B	487		`467A GLY 3.550Å` `468A TYR 3.613Å` `469A LYS 5.711Å` `472A GLY 5.486Å` `473A SER 5.561Å` `474A GLY 5.339Å` `475A ARG 2.899Å`
9	1o05_1	A	487		`467B GLY 3.487Å` `468B TYR 3.530Å` `469B LYS 5.616Å` `472B GLY 5.341Å` `473B SER 5.438Å` `474B GLY 5.279Å` `475B ARG 2.888Å`
10	1o02_2	H	487	`4808H GAI 4.634Å`	`467G GLY 3.265Å` `468G TYR 3.379Å` `469G LYS 5.571Å` `472G GLY 5.368Å` `473G SER 5.517Å` `474G GLY 5.314Å` `475G ARG 2.898Å`
11	1o02_2	G	487	`4807G GAI 4.609Å`	`467H GLY 3.456Å` `468H TYR 3.466Å` `469H LYS 5.655Å` `472H GLY 5.363Å` `473H SER 5.548Å` `474H GLY 5.363Å` `475H ARG 2.903Å`
12	1o02_2	F	487	`4806F GAI 4.607Å`	`467E GLY 3.333Å` `468E TYR 3.518Å` `469E LYS 5.509Å` `472E GLY 5.344Å` `473E SER 5.446Å` `474E GLY 5.352Å` `475E ARG 2.883Å`
13	1o02_2	E	487	`4805E GAI 4.635Å`	`467F GLY 3.395Å` `468F TYR 3.468Å` `469F LYS 5.604Å` `472F GLY 5.374Å` `473F SER 5.502Å` `474F GLY 5.350Å` `475F ARG 2.892Å`
14	1o02_1	D	487	`4804D GAI 4.619Å`	`467C GLY 3.327Å` `468C TYR 3.516Å` `469C LYS 5.608Å` `472C GLY 5.339Å` `473C SER 5.492Å` `474C GLY 5.356Å` `475C ARG 2.801Å`
15	1o02_1	C	487	`4803C GAI 4.619Å`	`467D GLY 3.416Å` `468D TYR 3.527Å` `469D LYS 5.599Å` `472D GLY 5.335Å` `473D SER 5.504Å` `474D GLY 5.420Å` `475D ARG 2.839Å`
16	1o02_1	B	487	`4802B GAI 4.741Å`	`467A GLY 3.373Å` `468A TYR 3.432Å` `469A LYS 5.582Å` `472A GLY 5.254Å` `473A SER 5.377Å` `474A GLY 5.270Å` `475A ARG 2.930Å`
17	1o02_1	A	487	`4801A GAI 4.464Å`	`467B GLY 3.343Å` `468B TYR 3.493Å` `469B LYS 5.496Å` `472B GLY 5.284Å` `473B SER 5.500Å` `474B GLY 5.361Å` `475B ARG 2.911Å`
18	1o01_2	H	487	`4808H GAI 4.861Å`	`467G GLY 3.243Å` `468G TYR 3.510Å` `469G LYS 5.266Å` `472G GLY 5.162Å` `473G SER 5.448Å` `474G GLY 5.347Å` `475G ARG 2.950Å`
19	1o01_2	G	487	`4807G GAI 4.592Å`	`467H GLY 3.477Å` `468H TYR 3.466Å` `469H LYS 5.452Å` `472H GLY 5.338Å` `473H SER 5.537Å` `474H GLY 5.291Å` `475H ARG 2.792Å`
20	1o01_2	F	487	`4806F GAI 4.550Å`	`467E GLY 3.351Å` `468E TYR 3.489Å` `469E LYS 5.423Å` `472E GLY 5.385Å` `473E SER 5.404Å` `474E GLY 5.285Å` `475E ARG 2.832Å`
21	1o01_2	E	487	`4805E GAI 4.697Å`	`467F GLY 3.378Å` `468F TYR 3.549Å` `469F LYS 5.515Å` `472F GLY 5.463Å` `473F SER 5.514Å` `474F GLY 5.268Å` `475F ARG 2.887Å`
22	1o01_1	D	487	`4804D GAI 4.442Å`	`467C GLY 3.401Å` `468C TYR 3.519Å` `469C LYS 5.425Å` `472C GLY 5.330Å` `473C SER 5.397Å` `474C GLY 5.252Å` `475C ARG 2.875Å`
23	1o01_1	B	487	`4802B GAI 4.528Å`	`467A GLY 3.470Å` `468A TYR 3.517Å` `469A LYS 5.499Å` `472A GLY 5.238Å` `473A SER 5.357Å` `474A GLY 5.203Å` `475A ARG 2.871Å`
24	1o01_1	A	487	`0.000Å`	`467B GLY 3.327Å` `468B TYR 3.517Å` `469B LYS 5.335Å` `472B GLY 5.158Å` `473B SER 5.372Å` `474B GLY 5.245Å` `475B ARG 2.907Å`
25	1o00_2	H	487		`467G GLY 3.318Å` `468G TYR 3.484Å` `469G LYS 5.595Å` `472G GLY 5.343Å` `473G SER 5.574Å` `474G GLY 5.390Å` `475G ARG 2.843Å`
26	1o00_2	G	487		`467H GLY 3.384Å` `468H TYR 3.467Å` `469H LYS 5.622Å` `472H GLY 5.432Å` `473H SER 5.664Å` `474H GLY 5.424Å` `475H ARG 2.754Å`
27	1o00_2	F	487		`467E GLY 3.487Å` `468E TYR 3.486Å` `469E LYS 5.521Å` `472E GLY 5.505Å` `473E SER 5.639Å` `474E GLY 5.439Å` `475E ARG 2.932Å`
28	1o00_2	E	487		`467F GLY 3.358Å` `468F TYR 3.524Å` `469F LYS 5.437Å` `472F GLY 5.303Å` `473F SER 5.618Å` `474F GLY 5.405Å` `475F ARG 2.924Å`
29	1o00_1	D	487		`467C GLY 3.389Å` `468C TYR 3.488Å` `469C LYS 5.561Å` `472C GLY 5.341Å` `473C SER 5.517Å` `474C GLY 5.311Å` `475C ARG 2.859Å`
30	1o00_1	C	487		`467D GLY 3.378Å` `468D TYR 3.508Å` `469D LYS 5.463Å` `472D GLY 5.418Å` `473D SER 5.629Å` `474D GLY 5.486Å` `475D ARG 2.953Å`
31	1o00_1	B	487		`467A GLY 3.490Å` `468A TYR 3.560Å` `469A LYS 5.639Å` `472A GLY 5.470Å` `473A SER 5.585Å` `474A GLY 5.336Å` `475A ARG 2.961Å`
32	1o00_1	A	487		`467B GLY 3.367Å` `468B TYR 3.498Å` `469B LYS 5.566Å` `472B GLY 5.394Å` `473B SER 5.571Å` `474B GLY 5.340Å` `475B ARG 2.843Å`
33	1nzz_2	H	487		`467G GLY 3.426Å` `468G TYR 3.528Å` `469G LYS 5.578Å` `472G GLY 5.291Å` `473G SER 5.608Å` `474G GLY 5.411Å` `475G ARG 3.141Å`
34	1nzz_2	G	487		`467H GLY 3.970Å` `468H TYR 3.432Å` `469H LYS 5.476Å` `472H GLY 5.731Å` `473H SER 5.896Å` `474H GLY 5.530Å` `475H ARG 2.792Å`
35	1nzz_2	F	487		`467E GLY 3.548Å` `468E TYR 3.420Å` `469E LYS 5.423Å` `472E GLY 5.254Å` `473E SER 5.516Å` `474E GLY 5.436Å` `475E ARG 2.981Å`
36	1nzz_2	E	487		`467F GLY 3.653Å` `468F TYR 3.462Å` `469F LYS 5.551Å` `472F GLY 5.486Å` `473F SER 5.736Å` `474F GLY 5.473Å` `475F ARG 2.963Å`
37	1nzz_1	D	487		`467C GLY 3.609Å` `468C TYR 3.478Å` `469C LYS 5.662Å` `472C GLY 5.572Å` `473C SER 5.808Å` `474C GLY 5.563Å` `475C ARG 2.771Å`
38	1nzz_1	C	487		`467D GLY 3.675Å` `468D TYR 3.424Å` `469D LYS 5.592Å` `472D GLY 5.320Å` `473D SER 5.602Å` `474D GLY 5.529Å` `475D ARG 3.119Å`
39	1nzz_1	B	487		`467A GLY 3.662Å` `468A TYR 3.553Å` `469A LYS 5.663Å` `472A GLY 5.312Å` `473A SER 5.512Å` `474A GLY 5.324Å` `475A ARG 2.957Å`
40	1nzz_1	A	487		`467B GLY 3.776Å` `468B TYR 3.537Å` `469B LYS 5.768Å` `472B GLY 5.552Å` `473B SER 5.678Å` `474B GLY 5.338Å` `475B ARG 2.722Å`
41	1nzx_2	H	487		`467G GLY 3.260Å` `468G TYR 3.577Å` `469G LYS 5.385Å` `472G GLY 5.097Å` `473G SER 5.417Å` `474G GLY 5.373Å` `475G ARG 3.255Å`
42	1nzx_2	G	487		`467H GLY 3.548Å` `468H TYR 3.626Å` `469H LYS 5.696Å` `472H GLY 5.426Å` `473H SER 5.616Å` `474H GLY 5.421Å` `475H ARG 2.842Å`
43	1nzx_2	F	487		`467E GLY 3.375Å` `468E TYR 3.336Å` `469E LYS 5.554Å` `472E GLY 5.339Å` `473E SER 5.544Å` `474E GLY 5.374Å` `475E ARG 2.801Å`
44	1nzx_2	E	487		`467F GLY 3.473Å` `468F TYR 3.540Å` `469F LYS 5.606Å` `472F GLY 5.270Å` `473F SER 5.500Å` `474F GLY 5.303Å` `475F ARG 3.109Å`
45	1nzx_1	D	487		`467C GLY 3.438Å` `468C TYR 3.590Å` `469C LYS 5.584Å` `472C GLY 5.380Å` `473C SER 5.608Å` `474C GLY 5.404Å` `475C ARG 2.808Å`
46	1nzx_1	C	487		`467D GLY 3.724Å` `468D TYR 3.442Å` `469D LYS 5.834Å` `472D GLY 5.491Å` `473D SER 5.621Å` `474D GLY 5.402Å` `475D ARG 3.010Å`
47	1nzx_1	B	487		`467A GLY 3.365Å` `468A TYR 3.620Å` `469A LYS 5.402Å` `472A GLY 5.192Å` `473A SER 5.484Å` `474A GLY 5.404Å` `475A ARG 2.936Å`
48	1nzx_1	A	487		`467B GLY 3.422Å` `468B TYR 3.560Å` `469B LYS 5.612Å` `472B GLY 5.255Å` `473B SER 5.478Å` `474B GLY 5.263Å` `475B ARG 2.857Å`
49	1cw3	H	487		`467G GLY 3.519Å` `468G TYR 3.440Å` `469G LYS 5.658Å` `472G GLY 5.509Å` `473G SER 5.509Å` `474G GLY 5.347Å` `475G ARG 2.956Å`
50	1cw3	G	487		`467H GLY 3.424Å` `468H TYR 3.425Å` `469H LYS 5.526Å` `472H GLY 5.518Å` `473H SER 5.571Å` `474H GLY 5.409Å` `475H ARG 2.795Å`
51	1cw3	F	487		`467E GLY 3.513Å` `468E TYR 3.531Å` `469E LYS 5.264Å` `472E GLY 5.378Å` `473E SER 5.323Å` `474E GLY 5.189Å` `475E ARG 3.039Å`
52	1cw3	E	487		`467F GLY 3.608Å` `468F TYR 3.330Å` `469F LYS 5.608Å` `472F GLY 5.550Å` `473F SER 5.540Å` `474F GLY 5.197Å` `475F ARG 2.870Å`
53	1cw3	D	487		`467C GLY 3.204Å` `468C TYR 3.338Å` `469C LYS 5.350Å` `472C GLY 5.222Å` `473C SER 5.376Å` `474C GLY 5.273Å` `475C ARG 2.768Å`
54	1cw3	C	487		`467D GLY 3.146Å` `468D TYR 3.375Å` `469D LYS 5.230Å` `472D GLY 5.336Å` `473D SER 5.523Å` `474D GLY 5.421Å` `475D ARG 2.895Å`
55	1cw3	B	487		`467A GLY 3.413Å` `468A TYR 3.450Å` `469A LYS 5.654Å` `472A GLY 5.465Å` `473A SER 5.582Å` `474A GLY 5.257Å` `475A ARG 2.791Å`
56	1cw3	A	487		`467B GLY 3.475Å` `468B TYR 3.547Å` `469B LYS 5.643Å` `472B GLY 5.599Å` `473B SER 5.515Å` `474B GLY 5.278Å` `475B ARG 2.813Å`
57	1o04_2	H	487	`6808H GAI 4.702Å`	`467G GLY 3.225Å` `468G TYR 3.439Å` `469G LYS 5.585Å` `472G GLY 5.253Å` `473G SER 5.448Å` `474G GLY 5.317Å` `475G ARG 2.945Å`
58	1o04_2	G	487	`6807G GAI 4.682Å`	`467H GLY 3.247Å` `468H TYR 3.477Å` `469H LYS 5.592Å` `472H GLY 5.195Å` `473H SER 5.467Å` `474H GLY 5.316Å` `475H ARG 2.916Å`
59	1o04_2	F	487	`6806F GAI 4.627Å`	`467E GLY 3.216Å` `468E TYR 3.428Å` `469E LYS 5.548Å` `472E GLY 5.211Å` `473E SER 5.414Å` `474E GLY 5.374Å` `475E ARG 2.924Å`
60	1o04_2	E	487	`6805E GAI 4.627Å`	`467F GLY 3.277Å` `468F TYR 3.488Å` `469F LYS 5.593Å` `472F GLY 5.237Å` `473F SER 5.531Å` `474F GLY 5.414Å` `475F ARG 2.935Å`
61	1o04_1	D	487	`6804D GAI 4.618Å`	`467C GLY 3.298Å` `468C TYR 3.471Å` `469C LYS 5.635Å` `472C GLY 5.253Å` `473C SER 5.494Å` `474C GLY 5.357Å` `475C ARG 2.911Å`
62	1o04_1	C	487	`6803C GAI 4.642Å`	`467D GLY 3.250Å` `468D TYR 3.494Å` `469D LYS 5.592Å` `472D GLY 5.219Å` `473D SER 5.416Å` `474D GLY 5.363Å` `475D ARG 2.880Å`
63	1o04_1	B	487	`6802B GAI 4.563Å`	`467A GLY 3.208Å` `468A TYR 3.455Å` `469A LYS 5.553Å` `472A GLY 5.230Å` `473A SER 5.417Å` `474A GLY 5.350Å` `475A ARG 2.922Å`
64	1o04_1	A	487	`6801A GAI 4.644Å`	`467B GLY 3.217Å` `468B TYR 3.484Å` `469B LYS 5.630Å` `472B GLY 5.231Å` `473B SER 5.497Å` `474B GLY 5.348Å` `475B ARG 2.864Å`
65	1nzw_2	H	487		`467G GLY 3.711Å` `468G TYR 3.539Å` `469G LYS 5.870Å` `472G GLY 5.532Å` `473G SER 5.486Å` `474G GLY 5.203Å` `475G ARG 3.078Å`
66	1nzw_2	G	487		`467H GLY 3.816Å` `468H TYR 3.505Å` `469H LYS 5.561Å` `472H GLY 5.661Å` `473H SER 5.645Å` `474H GLY 5.325Å` `475H ARG 2.903Å`
67	1nzw_2	F	487		`467E GLY 3.491Å` `468E TYR 3.429Å` `469E LYS 5.484Å` `472E GLY 5.352Å` `473E SER 5.530Å` `474E GLY 5.474Å` `475E ARG 2.869Å`
68	1nzw_2	E	487		`467F GLY 3.433Å` `468F TYR 3.510Å` `469F LYS 5.603Å` `472F GLY 5.433Å` `473F SER 5.540Å` `474F GLY 5.401Å` `475F ARG 2.929Å`
69	1nzw_1	D	487		`467C GLY 3.789Å` `468C TYR 3.519Å` `469C LYS 5.659Å` `472C GLY 5.648Å` `473C SER 5.586Å` `474C GLY 5.270Å` `475C ARG 3.005Å`
70	1nzw_1	C	487		`467D GLY 3.518Å` `468D TYR 3.441Å` `469D LYS 5.604Å` `472D GLY 5.386Å` `473D SER 5.541Å` `474D GLY 5.467Å` `475D ARG 3.072Å`
71	1nzw_1	B	487		`467A GLY 3.539Å` `468A TYR 3.666Å` `469A LYS 5.761Å` `472A GLY 5.371Å` `473A SER 5.336Å` `474A GLY 5.161Å` `475A ARG 2.837Å`
72	1nzw_1	A	487		`467B GLY 4.020Å` `468B TYR 3.408Å` `469B LYS 5.773Å` `472B GLY 5.857Å` `473B SER 5.710Å` `474B GLY 5.267Å` `475B ARG 2.725Å`
73	1ag8	D	487		`467C GLY 4.037Å` `468C TYR 3.626Å` `473C SER 5.856Å` `474C GLY 5.346Å` `475C ARG 3.706Å`
74	1ag8	C	487		`467D GLY 3.540Å` `468D TYR 3.474Å` `469D LYS 5.868Å` `473D SER 5.989Å` `474D GLY 5.653Å` `475D ARG 3.077Å`
75	1ag8	B	487		`467A GLY 3.940Å` `468A TYR 3.315Å` `474A GLY 5.564Å` `475A ARG 3.285Å`
76	1ag8	A	487		`467B GLY 3.531Å` `468B TYR 3.353Å` `469B LYS 5.865Å` `474B GLY 5.783Å` `475B ARG 2.747Å`
77	1a4z	D	487		`467C GLY 3.224Å` `468C TYR 3.448Å` `469C LYS 5.896Å` `473C SER 5.634Å` `474C GLY 5.375Å` `475C ARG 3.259Å`
78	1a4z	C	487		`467D GLY 3.196Å` `468D TYR 3.500Å` `469D LYS 5.899Å` `473D SER 5.630Å` `474D GLY 5.375Å` `0.000Å`
79	1a4z	B	487		`467A GLY 3.316Å` `468A TYR 3.388Å` `469A LYS 5.768Å` `472A GLY 5.790Å` `473A SER 5.360Å` `474A GLY 5.237Å` `475A ARG 3.003Å`
80	1a4z	A	487		`467B GLY 3.321Å` `468B TYR 3.251Å` `473B SER 5.622Å` `474B GLY 5.358Å` `475B ARG 2.918Å`
81	1bxs	D	487		`467C GLY 3.902Å` `468C PHE 3.702Å` `469C LYS 5.794Å` `472C GLY 5.586Å` `474C GLY 5.339Å` `475C ARG 3.144Å`
82	1bxs	C	487		`467D GLY 3.939Å` `468D PHE 3.718Å` `469D LYS 5.796Å` `472D GLY 5.620Å` `474D GLY 5.391Å` `475D ARG 3.186Å`
83	1bxs	B	487		`467A GLY 3.951Å` `468A PHE 3.795Å` `469A LYS 5.835Å` `472A GLY 5.577Å` `474A GLY 5.296Å` `475A ARG 3.192Å`
84	1bxs	A	487		`467B GLY 3.923Å` `468B PHE 3.768Å` `469B LYS 5.837Å` `472B GLY 5.563Å` `474B GLY 5.266Å` `475B ARG 3.140Å`
85	1bi9	D	487		`448C ALA 5.944Å`
87	1o9j	D	487		`467C GLY 3.418Å` `468C PHE 3.727Å` `469C LYS 5.624Å` `472C GLY 5.198Å` `473C HIS 5.175Å` `474C GLY 5.370Å` `475C ARG 2.843Å`
88	1o9j	C	487		`467D GLY 3.387Å` `468D PHE 3.720Å` `469D LYS 5.321Å` `472D GLY 4.841Å` `473D HIS 5.045Å` `474D GLY 5.248Å` `475D ARG 3.166Å`
89	1o9j	B	487		`467A GLY 3.392Å` `468A PHE 3.608Å` `469A LYS 5.429Å` `472A GLY 5.270Å` `473A HIS 5.315Å` `474A GLY 5.441Å` `475A ARG 2.980Å`
90	1o9j	A	487		`467B GLY 3.423Å` `468B PHE 3.761Å` `469B LYS 5.431Å` `472B GLY 5.279Å` `473B HIS 5.390Å` `474B GLY 5.576Å` `475B ARG 2.735Å` `480B TYR 5.949Å`