We use quantitative whole genome and proteome measures to guide
computational modeling of regulatory and enzymatic networks in microbial
and mammalian cells. We develop technologies based on bioinformatics,
microarrays, mass-spectrometry, automation, multiplexing, microfluidics,
and homologous-recombination genome engineering. We have recently used
these to discover new regulatory motifs involved in cell-cycle control,
stress response, and many other network components.
