Job Opportunities

The Genetics Division, Department of Medicine at Brigham & Women's Hospital and Harvard Medical School seeks an outstanding Assistant Professor level scientist in one of the above areas. Applicants should possess Ph.D., M.D., or M.D., Ph.D. degrees and have several years of relevant postdoctoral experience. Areas of interest are broad, and include genetic and systems level analyses of pathways involved in disease and development, stem cells, tissue and organ regeneration, and proteomics. The successful applicant will enjoy an outstanding competitive start-up package, excellent space and state-of-the-art facilities, and will be able to interact with strong existing expertise in human and mouse developmental genetics, computational genetics, signal transduction and genomics. Please send a CV, 1 page description of research interests, 2 page research proposal and 3 recommendation letters by Nov. 30 to:

A postdoctoral position in computational biology is available at the Sunyaev lab, Genetics Division, Brigham & Women's Hospital, Harvard Medical School. The position is funded for four years. The research project will be devoted to the analysis of human genetic variation and, specifically, to the systematic resequencing data. We are broadly interested in the effect of mutations on molecular function, phenotype and fitness. Areas of interest include development of computational methods for predicting functionally significant human alleles, development of data-driven population genetics models, simulations of resequencing studies of phenotypes populations, and design of statistical methods to relate DNA sequence data to phenotypes. We are looking for individuals with experience in population genetics, comparative genomics and/or development of bioinformatics methods. Familiarity with protein structures is a plus.

Application and inquiries should be submitted by e-mail to:
Shamil Sunyaev <ssunyaev@rics.bwh.harvard.edu>.

A postdoctoral position in computational biology, with a focus on proteomics, is available at the Sunyaev lab, Genetics Division, Brigham & Women's Hospital, Harvard Medical School. The position is funded for five years and is part of a large multidisciplinary effort aimed at the analysis of mammalian organogenesis and development of methods for organ engineering. The research project will be devoted to computational approaches to proteomics of mammalian organ development. It will involve computational identification of proteins and protein modifications from mass spectrometry data and bioinformatic analysis of time series proteomic data during endogenous and in vitro organ development. These analyses will be assisted by accumulated expression data and ongoing experimental studies and will potentially inform the quantitative modeling of mammalian organogenesis. The project will involve a close collaboration with Dr. Steve Gygi, Director of Taplin Mass Spectrometry Facility at Harvard Medical School, and several developmental biology, bioengineering, genomic technology and computational biology groups.

Application and inquiries should be submitted by e-mail to:
Shamil Sunyaev <ssunyaev@rics.bwh.harvard.edu>.

There is a technician / research assistant position available for a highly motivated individual with prior on-the-job experience in a molecular biology research laboratory. Prior laboratory experience in yeast genetics is preferable but not required. This research project will focus on interactions between transcription factors and their DNA binding sites, both in the yeast Saccharomyces cerevisiae and in the mouse genome. These data will serve to more accurately annotate the yeast and mouse genomes and to understand mechanisms of transcriptional regulation. In this project, you will gain valuable skills in: expression and purification of recombinant proteins from E. coli, growth of yeast cultures, yeast tetrad dissections, chromatin immunoprecipitations, gene expression profiling, quantitative real-time PCR, protein binding microarray experiments, microarray data analysis, and genome sequence analysis. Other duties will include maintaining equipment and supplies.

This position also offers the opportunity to gain valuable written and oral communication skills, and the possibility for co-authorship on publications. Applicant must be able to work in a Windows PC environment and have basic computer proficiency. A flexible work schedule is preferable. A recent Bachelor of Science degree in a biological science is required. Applicants with a bachelor's degree in another area of concentration may be considered if the applicant has had significant coursework in the sciences, has the required prior laboratory work experience, and demonstrates strong potential. This position is ideal for a recent college graduate seeking to gain additional laboratory research experience. Fluent command of spoken and written English is absolutely required.šThe highly experienced individual who demonstrates good laboratory practices and interpersonal skills may have the opportunity for future supervisory roles.

This position offers a stimulating, academic environment, and the opportunity to work in a team setting. The lab is in the Division of Genetics at Brigham & Women's Hospital, part of the Harvard Medical School research community. This position provides an excellent opportunity to be involved in cutting-edge genomics research while studying transcriptional regulation. Salary negotiable based upon work experience.

To apply for this position, please email a cover letter, resume, and contact information for 3 references to: mlbulyk@receptor.med.harvard.edu

There is a full-time position available for an individual proficient in Perl, C/C++, Java, SQL, and MySQL/Oracle. Solid experience with compilers and Linux/Unix is required. Experience in HTML, Javascript, and CSS, and with R or MATLAB, is preferable. Experience working in a Linux cluster environment and with the use of suffix trees is a plus. A Bachelor of Science degree in computer science is required, and some prior coursework in molecular biology and/or genetics would be helpful. A flexible work schedule is preferable.

We are an academic research lab focused on the development and application of genome sequence analysis methods, in order to understand genetic regulatory networks and features of functional regulatory regions in genomes. The lab is in the Division of Genetics at Brigham & Women's Hospital, part of the Harvard Medical School research community at the Longwood Medical Area in Boston, and is located in the Harvard Medical School New Research Building.

This position offers a stimulating, academic environment, and the opportunity to work in a team setting together with graduate students, postdoctoral fellows, and research staff. This position provides an excellent opportunity to be involved in cutting-edge research, while learning about genome biology and evolution. There is significant opportunity for publication of research efforts in scientific journals. The highly experienced individual who demonstrates productivity and interpersonal skills may have the opportunity for future supervisory roles. Fluent command of spoken and written English is absolutely required.

Salary negotiable based upon background and work experience. Competitive fringe benefits are provided. To apply for this position, please send a cover letter, resume, and contact information for 3 references to: